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- Title
COGENT (COlorectal Cancer GENeTics): An International Consortium To Study The Role Of Polymorphic Variation On The Risk Of Colorectal Cancer.
- Authors
Tomlinson, I. P. M.; Dunlop, M.; Campbell, H.; Zanke, B.; Gallinger, S.; Hudson, T.; Koessler, T.; Pharoah, P. D.; Niittymäkix, I.; Tuupanenx, S.; Aaltonen, L. A.; Hemminki, K.; Lindblom, A.; Försti, A.; Sieber, O.; Lipton, L.; Wezel, T. van; Morreau, H.; Wijnen, J. T.; Devilee, P.
- Abstract
It is now recognised that a part of the inherited risk of colorectal cancer (CRC) can be explained by the co-inheritance of low-penetrance genetic variants. The accumulated experience to date in identifying these variants has served to highlight difficulties in conducting statistically and methodologically rigorous studies and follow-up analyses. The COGENT (COlorectal cancer GENeTics) consortium includes 20 research groups in Europe, Australia, the Americas, China and Japan. The overarching goal of COGENT is to identify and characterise low-penetrance susceptibility variants for CRC through association-based analyses. In this study, we review the rationale for identifying low-penetrance variants for CRC and our proposed strategy for establishing COGENT.
- Subjects
EUROPE; AUSTRALIA; JAPAN; COLON cancer risk factors; FOLLOW-up studies (Medicine); HUMAN genetic variation; GENE frequency; HUMAN genome
- Publication
Asia-Pacific Journal of Oncological Medicine, 2010, Vol 2, Issue 1, p100
- ISSN
2042-4965
- Publication type
Article
- DOI
10.5083/apjom.20424965.19