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- Title
Correlation of Mean Platelet Volume with Glycosylated Haemoglobin and Microvascular Complications in Type 2 Diabetes Mellitus Patients.
- Authors
R., Mohan Kumar; Singh, W. P.; Hasan, Zaheerul; Singh, K. P.
- Abstract
Background: The long-term complications of DM have a variety of severe effects on people's quality of life as well as their prospective life, harming both individuals and civilizations. In order to reduce the microvascular and macrovascular complications, glycated haemoglobin (HbA1c), should be maintained below 7% in DMT2 patients. It is possible to predict complications in type 2 DM using the simple, reliable, and affordable tests like Mean Platelet Volume (MPV). Methods: A Prospective Cohort Study was taken among 106 patients from patients with a diagnosis of T2DM attending OPD and IPD of the Department of Medicine during the study period from 1st of February 2021 to 30th September 2022. Those who are fulfilling the criteria were included and the study was analysed as per objectives. Results: In the current study, there was no significant difference in the participants' mean Fasting Blood Sugar (FBS), there was a statistically significant difference between the two groups when it came to mean post-prandial blood sugar in the current study. The mean Urinary ACR for participants with adequate glycaemic control was 25.7313.76 mg/g, while it was 35.4021.63 mg/g for people with poor glycaemic control. With a p-value of 0.012, this difference between the two groups was significant. The mean MPV of the participants was 8.77 in the group without diabetic retinopathy and 10.51 in the group with diabetic retinopathy, respectively and the difference is statistically significant. The mean MPV of the participants was 8.56 in the group without diabetic nephropathy and 10.57 in the group with diabetic nephropathy, respectively and the difference is highly significant. Hba1c levels and MPV levels have a significant positive connection in the current investigation. Pearson's R Correlation score indicates a correlation of 0.753, with a p-value of 0.000.Conclusions: Our research leads us to the conclusion that platelets in diabetes mellitus have an increased mean volume (MPV) and become more reactive and aggregable. The increased risk of diabetic retinopathy, and diabetic nephropathy associated with diabetes mellitus and its consequences may be partially attributed to the larger platelets. MPV might therefore be a helpful predictive indicator of problems in diabetes.
- Subjects
MEAN platelet volume; TYPE 2 diabetes; DIABETIC retinopathy; PEOPLE with diabetes; GLYCEMIC control; PEARSON correlation (Statistics); HEMOGLOBINS
- Publication
European Journal of Cardiovascular Medicine, 2023, Vol 13, Issue 1, p361
- ISSN
2042-4884
- Publication type
Article