We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Sweet Bee Venom Triggers Multiple Cell Death Pathways or Spurs Acute Cell Rupture According to Its Concentration in THP-1 Monocytic Leukemia Cells.
- Authors
Ryu, Jae-Min; Na, Han-Heom; Park, Yoon-Jong; Park, Jin-Sung; Ahn, Byung-Soo; Kim, Keun-Cheol
- Abstract
Sweet bee venom (sBV) contains various pharmacologically active components of bee venom (BV), but it is modified via the removal of the harmful substances found in BV. Thus, sBV has been used for pain relief in Oriental medicine but has only recently been applied for the treatment of various diseases. In this study, we examined the pharmacological effects and immunomodulatory functions of sBV in THP-1 monocytic leukemia cells. Growth inhibition and cell death were observed according to the concentration of sBV. However, the rapid collapse of cell cycle distribution was shown at 20 μg/mL sBV treatment, indicating that sBV led to cell death or acute cell rupture according to concentration. sBV administration activated Caspase-9, PARP1, RIPK1, and RIPK3, suggesting that the pharmacological actions of sBV were associated with induction of apoptosis and necroptosis. On the other hand, sBV or LPS administration increased cytokine expression, including IL-1β, and showed synergistic cell death in combinatory treatment conditions. Moreover, combinatory administration of sBV and LPS induced severe damage or death during egg development. This result implies that sBV exhibits both pharmacological and toxic effects depending on its concentration. Therefore, sBV might be a promising therapeutic approach, but optimal concentration should be considered before treatment.
- Subjects
BEE venom; CELL death; CELL death inhibition; CELL cycle; POISONS; ASIAN medicine
- Publication
Genes, 2022, Vol 13, Issue 2, p223
- ISSN
2073-4425
- Publication type
Article
- DOI
10.3390/genes13020223