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- Title
ATM: Main Features, Signaling Pathways, and Its Diverse Roles in DNA Damage Response, Tumor Suppression, and Cancer Development.
- Authors
Phan, Liem Minh; Rezaeian, Abdol-Hossein
- Abstract
ATM is among of the most critical initiators and coordinators of the DNA-damage response. ATM canonical and non-canonical signaling pathways involve hundreds of downstream targets that control many important cellular processes such as DNA damage repair, apoptosis, cell cycle arrest, metabolism, proliferation, oxidative sensing, among others. Of note, ATM is often considered a major tumor suppressor because of its ability to induce apoptosis and cell cycle arrest. However, in some advanced stage tumor cells, ATM signaling is increased and confers remarkable advantages for cancer cell survival, resistance to radiation and chemotherapy, biosynthesis, proliferation, and metastasis. This review focuses on addressing major characteristics, signaling pathways and especially the diverse roles of ATM in cellular homeostasis and cancer development.
- Subjects
DNA damage; AUTOMATED teller machines; CELL survival; TUMOR suppressor proteins; DNA repair; HOMEOSTASIS; WNT signal transduction; CANCER cells
- Publication
Genes, 2021, Vol 13, Issue 6, p845
- ISSN
2073-4425
- Publication type
Article
- DOI
10.3390/genes12060845