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- Title
A case of dedifferentiated liposarcoma with an unusual clinical course.
- Authors
Stevenson, Margaret K.; Howarth, David J.; Wunder, Jay S.; Dickson, Brendan C.
- Abstract
Objective: Dedifferentiated liposarcoma (DD-LPS) is a high-grade sarcoma associated with frequent local recurrence, distant metastasis and mortality. DD-LPS has a less aggressive clinical course than other high-grade sarcomas, such as undifferentiated pleomorphic sarcoma. Nevertheless, in contrast to well-differentiated liposarcoma (WD-LPS), it is not reported to be associated with indolent behaviour. Data and results: A 51-year-old female presented to an outside institution in 1997 with a thigh lesion. A core biopsy at the time was diagnosed as neurofibroma and the patient elected not to have the mass resected. The tumour slowly increased over 19 years until the patient was referred to our institution with a 20 cm mass. A core biopsy revealed areas of WD- and DD-LPS, an interpretation confirmed with immunoexpression of MDM2 and amplification of MDM2 by fluorescence in situ hybridization. The original 1997 biopsy was re-reviewed for comparison. Morphologically it was consistent with DD-LPS and this was again confirmed by immunohistochemistry and molecular cytogenetics. Subsequent staging investigations failed to demonstrate evidence of metastasis. Conclusions: The diagnosis of DD-LPS can be challenging, particularly in limited samples. Ancillary techniques are increasingly valuable in subtyping mesenchymal neoplasms. Not only does this case highlight an essential role for ancillary testing, it raises the possibility that, in some instances, DD-LPS may be associated with somewhat more indolent clinical behaviour.
- Publication
Canadian Journal of Pathology, 2016, Vol 8, p35
- ISSN
1918-915X
- Publication type
Article