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- Title
Gentamicin susceptibility of Neisseria gonorrhoeae isolates from 7 provinces in China.
- Authors
Liu, Jing-Wei; Xu, Wen-Qi; Zhu, Xiao-Yu; Dai, Xiu-Qin; Chen, Shao-Chun; Han, Yan; Liu, Jun; Chen, Xiang-Sheng; Yin, Yue-Ping
- Abstract
Purpose: Gentamicin is a promising antimicrobial for the treatment of gonorrhea. The study aimed to evaluate gentamicin minimum inhibitory concentrations (MICs) of Neisseria gonorrhoeae isolates in China. Methods: In this study, the agar dilution method was used to determine the MICs of 470 isolates collected in 2016 to four effective antimicrobials (gentamicin, azithromycin, ceftriaxone, and spectinomycin). Results: Gentamicin MICs ranged from 1 to 8 mg/L. No isolate was resistant to gentamicin. Of seven isolates simultaneously resistant to azithromycin and ceftriaxone, 6 isolates demonstrated MICs of 4 mg/L or less to gentamicin. No cross relationships were found between MICs of gentamicinand susceptibility profiles of azithromycin, ceftriaxone, and spectinomycin. Conclusion: The in vitro results suggest that gentamicin can be a promising treatment option for gonococcal infections in China. Clinical trials to evaluate the therapeutic efficacy of gentamicin are required.
- Subjects
CHINA; NEISSERIA gonorrhoeae; CEFTRIAXONE; AZITHROMYCIN; GENTAMICIN; NEISSERIA; GONORRHEA; PROVINCES
- Publication
Infection & Drug Resistance, 2019, Vol 12, p2471
- ISSN
1178-6973
- Publication type
Article
- DOI
10.2147/IDR.S214059