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- Title
Topical Vitamin C and the Skin: Mechanisms of Action and Clinical Applications.
- Authors
AL-NIAIMI, FIRAS; NICOLE YI ZHEN CHIANG; Chiang, Nicole Yi Zhen
- Abstract
OBJECTIVE: This review article details the main mechanisms of action and clinical applications of topical vitamin C on the skin, including its antioxidative, photoprotective, antiaging, and antipigmentary effects. DESIGN: A PubMed search for the relevant articles on vitamin C and the skin was conducted using the following key words: "vitamin C," "ascorbic acid," "ascorbyl-6-palmitate,"and "magnesium ascorbyl phosphate." RESULTS: As one of the most powerful antioxidants in the skin, vitamin C has been shown to protect against photoaging, ultraviolet-induced immunosuppression, and photocarcinogenesis. It also has an antiaging effect by increasing collagen synthesis, stabilizing collagen fibers, and decreasing collagen degradation. It decreases melanin formation, thereby reducing pigmentation. Vitamin C is the primary replenisher of vitamin E and works synergistically with vitamin E in the protection against oxidative damage. CONCLUSION: Topical vitamin C has a wide range of clinical applications, from antiaging and antipigmentary to photoprotective. Currently, clinical studies on the efficacy of topical formulations of vitamin C remain limited, and the challenge lies in finding the most stable and permeable formulation in achieving the optimal results.
- Subjects
VITAMIN content of food; THERAPEUTIC use of vitamin C; IMMUNOSUPPRESSION; VITAMIN C deficiency; PREVENTION; VITAMIN deficiency
- Publication
Journal of Clinical & Aesthetic Dermatology, 2017, Vol 10, Issue 7, p14
- ISSN
1941-2789
- Publication type
journal article