Microneedling plus topical dutasteride solution for androgenetic alopecia: a randomized placebo‐controlled study.

Sánchez‐Meza, E.; Ocampo‐Candiani, J.; Gómez‐Flores, M.; Herz‐Ruelas, M.E.; Ocampo‐Garza, J.; Orizaga‐y‐Quiroga, T.L.; Martínez‐Moreno, A.; Ocampo‐Garza, S.S.

Microneedling plus topical dutasteride solution for androgenetic alopecia: a randomized placebo-controlled study Secondary outcomes were changes in hair density, hair thickness, ratio of vellus hair/terminal hair (RVHTH) and quality of life using the Dermatology Life Quality Index (DLQI). Microneedling is a minimally invasive technique consisting of sterile microneedles for repetitive cutaneous puncturing that increase hair regrowth by growth factor release.1,2 Oral dutasteride is a dual 5- -reductase inhibitor used off-label for androgenetic alopecia (AGA)3 with higher effectiveness and similar safety profile than oral finasteride.4,5 However, some patients express concern about the low risk of sexual adverse events (AE) with oral administration of 5- -reductase inhibitors.6,7 Saceda-Corralo I et al i . reported no systemic androgen level modification with intralesional dutasteride solution.8 We proposed that microneedling (MN) plus topical dutasteride solution could be another therapeutic option for AGA; to date, no study has analysed its efficacy.

BALDNESS; TOPICAL drug administration; ORAL drug administration

Journal of the European Academy of Dermatology & Venereology, 2022, Vol 36, Issue 10, pe806

0926-9959

Academic Journal

10.1111/jdv.18285