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- Title
The Role of c-MYC in B-Cell Lymphomas: Diagnostic and Molecular Aspects.
- Authors
Nguyen, Lynh; Papenhausen, Peter; Shao, Haipeng
- Abstract
c-MYC is one of the most essential transcriptional factors, regulating a diverse array of cellular functions, including proliferation, growth and apoptosis. Dysregulation of c-MYC is essential in the pathogenesis of a number of B-cell lymphomas, but is rarely reported in T-cell lymphomas. c-MYC dysregulation induces lymphomagenesis by loss of the tight control of c-MYC expression, leading to overexpression of intact c-MYC protein, in contrast to the somatic mutations or fusion proteins seen in many other oncogenes. Dysregulation of c-MYC in B-cell lymphomas occurs either as a primary event in Burkitt lymphoma, or secondarily in aggressive lymphomas such as diffuse large B-cell lymphoma, plasmablastic lymphoma, mantle cell lymphoma, or double-hit lymphoma. Secondary c-MYC changes include gene translocation and gene amplification, occurring against a background of complex karyotype and most often confer aggressive clinical behavior, as evidenced in the double-hit lymphomas. In low-grade B-cell lymphomas, acquisition of c-MYC rearrangement usually results in transformation into highly aggressive lymphomas, with some exceptions. In this review, we discuss the role that c-MYC plays in the pathogenesis of B-cell lymphomas, the molecular alterations that lead to c-MYC dysregulation and their effect on prognosis and diagnosis in specific types of B-cell lymphoma.
- Subjects
RETICULOENDOTHELIAL granulomas; HEMATOLOGIC malignancies; LYMPHOPROLIFERATIVE disorders; IMMUNOGLOBULIN class switching; ANTIGEN presenting cells
- Publication
Genes, 2017, Vol 8, Issue 4, p116
- ISSN
2073-4425
- Publication type
Article
- DOI
10.3390/genes8040116