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- Title
Association of pulse pressure with all-cause mortality in young adults.
- Authors
Jie LI; Jia-Yi Huang; Kenneth Lo; Bin Zhang; Yu-Qing Huang; Ying Qing Feng; Li, Jie; Huang, Jia-Yi; Lo, Kenneth; Zhang, Bin; Huang, Yu-Qing; Feng, Ying Qing
- Abstract
<bold>Background: </bold>Pulse blood pressure was significantly associated with all-cause mortality in middle-aged and elderly populations, but less evidence was known in young adults.<bold>Objective: </bold>To assess the association of pulse pressure (PP) with all-cause mortality in young adults.<bold>Methods: </bold>This cohort from the 1999-2006 National Health and Nutrition Examination Survey included adults aged 18-40 years. All included participants were followed up until the date of death or 31 December 2015. PP was categorised into three groups: <50, 50~60, ≥60 mm Hg. Cox proportional hazards models and subgroup analysis were performed to estimate the adjusted HRs and 95% CIs for all-cause mortality.<bold>Results: </bold>After applying the exclusion criteria, 8356 participants (median age 26.63±7.01 years, 4598 women (55.03%)) were included, of which 265 (3.17%) have died during a median follow-up duration of 152.96±30.45 months. When treating PP as a continuous variable, multivariate Cox analysis showed that PP was an independent risk factor for all-cause mortality (HR 1.94, 95% CI 1.02 to 3.69; p=0.0422). When using PP<50 mm Hg as referent, from the 50~60 mm Hg to the ≥60 mm Hg group, the risks of all-cause mortality for participants with PP ranging 50-60 mm Hg or ≥60 mm Hg were 0.93 (95% CI 0.42 to 2.04) and 1.15 (95% CI 0.32 to 4.07) (P for tend was 0.959). Subgroup analysis showed that PP (HR 2.00, 95% CI 1.05 to 3.82; p=0.0360) was associated with all-cause mortality among non-hypertensive participants.<bold>Conclusion: </bold>Among young adults, higher PP was significantly associated with an increased risk of all-cause mortality, particularly among those without hypertension.
- Subjects
YOUNG adults; HEALTH &; Nutrition Examination Survey; PROPORTIONAL hazards models
- Publication
Postgraduate Medical Journal, 2020, Vol 96, Issue 1138, p461
- ISSN
0032-5473
- Publication type
journal article
- DOI
10.1136/postgradmedj-2019-137070