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- Title
Depression of factor XII-dependent fibrinolytic activity in survivors of acute myocardial infarction at risk of reinfarction.
- Authors
PEDERSEN, O. D.; MUNKVAD, S.; GRAM, J.; KLUFT, C.; JESPERSEN, J.
- Abstract
Defective fibrinolysis may constitute a risk for the development of myocardial infarction in patients with ischaemic heart disease. We studied prospectively the factor XII-dependent plasminogen proactivator system in 49 survivors of an acute myocardial infarction. Blood samples were collected 8 weeks after hospital discharge. The factor XII-dependent fibrinolytic activity in the specimens was determined on fibrin plates after complete immuno-inhibition of the urokinase-like and the t-PA related fibrinolytic systems. During the subsequent follow-up period of 2.4 years, 10 patients developed recurrent myocardial infarction, whereas the remaining 39 patients did not. The reinfarction group of patients had a signficantly lower median factor XII-dependent fibrinolytic activity (24.9 blood activating units (BAU) . ml) than the patients without a relapse (41.9 BAU . ml, < 0.02). Plasma concentrations of factor XII did not deviate significantly between the groups ( > 0.05), whereas the median plasma concentrations of prekallikrein was slightly lower in the reinfarction group (90%) than in the non-reinfarction group of patients (105%, < 0.02). These observations point to an association between a depressed factor XII-dependent fibrinolytic activity and an enhanced risk of reinfarction in patients with a previous episode of acute myocardial infarction.
- Publication
European Heart Journal, 1993, Vol 14, Issue 6, p785
- ISSN
0195-668X
- Publication type
Article
- DOI
10.1093/eurheartj/14.6.785