We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Elution of autoantibodies from the hearts of Coxsackievirus-infected mice.
- Authors
Neumann, D. A.; Lane, J. R.; LaFond-Walker, A.; Allen, G. S.; Frondoza, C.; Herskowitz, A.; Rose, N. R.
- Abstract
Circulating heart-reactive antibodies are commonly reported in myocarditis and cardiomyopathy patients. While these observations support the hypothesis that autoimmune mechanisms may be involved in pathogenesis, such evidence is largely circumstantial. The current studies demonstrate that heart-reactive antibodies can be eluted from the hearts of Coxsackievirus B3-infected A/J mice with post-infectious autoimmune myocarditis, but not from the hearts of infected B10.A mice which are resistant to autoimmune myocarditis. The eluted antibodies recognize fewer cardiac antigens than are recognized by circulating antibodies. These results provide an opportunity to examine the role of autoantibodies in the pathogenesis of chronic myocarditis.
- Publication
European Heart Journal, 1991, Vol 12, Issue suppl_D, p113
- ISSN
0195-668X
- Publication type
Article
- DOI
10.1093/eurheartj/12.suppl_d.113