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- Title
DNA-Programmed Dynamic Assembly of Quantum Dots for Molecular Computation.
- Authors
He, Xuewen; Li, Zhi; Chen, Muzi; Ma, Nan
- Abstract
Despite the widespread use of quantum dots (QDs) for biosensing and bioimaging, QD-based bio-interfaceable and reconfigurable molecular computing systems have not yet been realized. DNA-programmed dynamic assembly of multi-color QDs is presented for the construction of a new class of fluorescence resonance energy transfer (FRET)-based QD computing systems. A complete set of seven elementary logic gates (OR, AND, NOR, NAND, INH, XOR, XNOR) are realized using a series of binary and ternary QD complexes operated by strand displacement reactions. The integration of different logic gates into a half-adder circuit for molecular computation is also demonstrated. This strategy is quite versatile and straightforward for logical operations and would pave the way for QD-biocomputing-based intelligent molecular diagnostics.
- Subjects
QUANTUM dots; BIOSENSORS; BIO-imaging sensors; FLUORESCENCE resonance energy transfer; LOGIC circuits
- Publication
Angewandte Chemie International Edition, 2014, Vol 53, Issue 52, p14447
- ISSN
1433-7851
- Publication type
Article
- DOI
10.1002/anie.201408479