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- Title
Importanţa clinică a modulării tratamentului cu Voriconazol în cazul aspergilozei pulmonare invazive pentru două cazuri de leucemie acută mieloblastică.
- Authors
NEAGU, Ana-Maria; VLĂDĂREANU, Ana Maria; BUMBEA, Horia; CÎŞLEANU, Diana
- Abstract
Background. Patients with acute leukemia are at high risk to develop invasive fungal infections, and Aspergillus spp is the most common pathogen. Aim. The two cases that are presented highlight the importance of adjusting the algorithm for diagnosis and treatment of invasive fungal infections in acute leukemia patients according to the particularities of each case in order to obtain an optimal response to the antifungal therapy. Methods and results. We present two cases of acute leukemia in young patients, who develop pulmonary invasive aspergillosis during severe neutropenia following chemotherapy. The diagnosis is clinical, mycrobiological, and esspecially imagistic, the CT scan revealing images typical for pulmonary invasive aspergillosis and allowing early antifungal therapy. Conclusions. The two cases illustrate the favourable outcome of patients with acute leukemia and pulmonary invasive aspergillosis when treated early with Voriconazole and the importance of dose adjusting according to clinical evolution.
- Subjects
LEUKEMIA treatment; ACUTE leukemia; PULMONARY aspergillosis; ANTIFUNGAL agents; THERAPEUTICS
- Publication
Romanian Journal of Medical Practice, 2015, Vol 10, Issue 1, p62
- ISSN
1842-8258
- Publication type
Article
- DOI
10.37897/rjmp.2015.1.10