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- Title
Application of exosomal miRNA mediated macrophage polarization in colorectal cancer: Current progress and challenges.
- Authors
YUN ZHANG; SHALING TANG; YUBO GAO; ZHONGTING LU; YUAN YANG; JING CHEN; TAO LI
- Abstract
Colorectal cancer (CRC) is a major global health problem with high morbidity and mortality rates. Surgical resection is the main treatment for early-stage CRC, but detecting it early is challenging. Therefore, effective therapeutic targets for advanced patients are still lacking. Exosomes, tiny vesicles in body fluids, play a crucial role in tumor metastasis, immune regulation, and drug resistance. Interestingly, they can even serve as a biomarker for cancer diagnosis and prognosis. Studies have shown that exosomes can carry miRNA, mediate the polarization of M1/M2 macrophages, promote the proliferation and metastasis of cancer cells, and affect the prognosis of CRC. Since the gastrointestinal tract has many macrophages, understanding the mechanism behind exosomal miRNA-mediated macrophage polarization in CRC treatment is crucial. This article summarizes recent advancements in the study of exosomal miRNAs in CRC and their potential as diagnostic and prognostic markers.
- Subjects
COLORECTAL cancer; EXOSOMES; PROGNOSIS; MICRORNA; MACROPHAGES
- Publication
Oncology Research, 2024, Vol 32, Issue 1, p61
- ISSN
0965-0407
- Publication type
Article
- DOI
10.32604/or.2023.043481