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- Title
Is very high platelet count always associated with essential thrombocythemia? An unusual presentation in a child.
- Authors
Aktekin, Elif Habibe; Yazici, Nalan; Kozanoğlu, İlknur; Erbay, Ayşe
- Abstract
Myeloproliferative neoplasms are rare in childhood. They are categorized as Philadelphia chromosome-positive and Philadelphia chromosome-negative. Chronic myeloid leukemia (CML) is the most common myeloproliferative disease in which the Philadelphia chromosome is detected as a result of BCR-ABL rearrangements. In others, the most common genetic abnormality is JAK2V617F mutation. The coexistence of these 2 abnormalities in CML is unexpected, and rare cases have recently been reported in adults. We present a child who had a very high platelet count in which we found this coexistence. The clinical presentation, laboratory findings, management, and prognosis of this coexistence is challenging in such a rare condition.
- Subjects
THROMBOCYTOSIS; ULTRASONIC imaging; GENETIC mutation; HYDROXYUREA; MAGNETIC resonance imaging; VOMITING; PLATELET count; ASPIRIN; HEADACHE; BLOOD testing; BONE marrow examination
- Publication
Laboratory Medicine, 2023, Vol 54, Issue 6, pe170
- ISSN
0007-5027
- Publication type
Article
- DOI
10.1093/labmed/lmad053