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- Title
Effect of selected 8-hydroxyquinoline-2-carboxanilides on viability and sulfate metabolism of Desulfovibrio piger.
- Authors
Kushkevych, Ivan; Vítězová, Monika; Kos, Jiří; Kollár, Peter; Jampílek, Josef
- Abstract
An increased number of sulfate-reducing bacteria is often isolated from faeces of patients with gastrointestinal diseases, which can be the cause of the development of bowel inflammation. Frequent use of antibiotics causes the resistance of intestinal microorganisms and ineffective treatment of these diseases. The antimicrobial activity and biological properties of the selected ring-substituted 8-hydroxyquinoline-2-carboxanilides against Desulfovibrio piger Vib-7 were studied. The addition of these compounds in the cultivation medium inhibited the bacterial growth and the process of sulfate reduction dose-dependently. A significant cytotoxic activity under the influence of ring-substituted 8-hydroxyquinoline-2-carboxanilides was determined. The strongest cytotoxic effect of the derivatives was observed for compounds 8-hydroxy- N -(3-methoxyphenyl)quinoline-2-carboxamide and 8-hydroxy- N -(3-trifluoromethylphenyl)quinoline-2-carboxamide that caused a low survival of D. piger Vib-7 in concentration 17 μM and high toxicity rates.
- Subjects
SULFATE-reducing bacteria; HYDROXYQUINOLINE; MICROORGANISM viability; BACTERIAL metabolism; ANILIDES; DESULFOVIBRIO
- Publication
Journal of Applied Biomedicine, 2018, Vol 16, Issue 3, p241
- ISSN
1214-021X
- Publication type
Article
- DOI
10.1016/j.jab.2018.01.004