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- Title
Kinetic Resolution of 1,1′-Biaryl-2,2′-Diols and Amino Alcohols through NHC-Catalyzed Atroposelective Acylation.
- Authors
Lu, Shenci; Poh, Si Bei; Zhao, Yu
- Abstract
We present here a highly efficient NHC-catalyzed kinetic resolution of a wide range of 1,1′-biaryl-2,2′-diols and amino alcohols to provide them in uniformly ≥99 % ee. This represents the first highly enantioselective catalytic acylation of axially chiral alcohols. The aldehyde backbone that is incorporated into the chiral acyl azolium intermediate was found to have a significant effect on the enantioselectivity of the process.
- Subjects
CHEMICAL kinetics; CHEMICAL affinity; REACTIVITY (Chemistry); SPECIFIC catalysis; RATE coefficients (Chemistry); AMINO alcohols; ACYLATION
- Publication
Angewandte Chemie International Edition, 2014, Vol 53, Issue 41, p11041
- ISSN
1433-7851
- Publication type
Article
- DOI
10.1002/anie.201406192