We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Pesquisa de interferon gama em tecido periodontal de ratos submetidos á movimentação dentária induzida.
- Authors
da Silveira, Daniel Mascarenhas; Franco, Fernanda Catharino Menezes; de Oliveira Nascimento, Ivana Lúcia; de Freitas Lima Salomão, Milene; de Araujo, Telma Martins
- Abstract
Introduction: During the orthodontic treatment, an inflammatory process is induced, triggering series of biochemical events that results in dental movement. Stimuli such as hypoxia and mechanical deformation are the main factors responsible for the breaking of cell homeostasis, resulting in stress and liberation of several important mediators for tooth movement. To occur osseous remodeling during orthodontic treatments, regulating factors such as sub products of arachidonic acid and cytokines are released. To interferon-gamma (INF-γ), a main cytokine released after induction of adaptive immune response, is attributed the function of attracting the macrophages, which aids in removing cell rests and promote healing and reorganization of the inflamed areas. Aim: Given that some biological aspects that permeate dental movement are not yet fully clear, we aimed in this study to investigate INF-γ expression in the periodontium of rats under orthodontic movement. Methods: The sample was composed of 9 rats, whose first upper right molars were moved with a force of 0,5N, for 3, 7 and 14 days. The left molars were used as controls. Results: Through immunohistochemistry, we verified the absence of INF-γ expression in almost all the studied tissues, in both the traction and pressure sides.
- Subjects
TOOTH mobility; INFLAMMATION; ORTHODONTICS; CYTOKINES; IMMUNE response; IMMUNOHISTOCHEMISTRY
- Publication
Revista Dental Press de Ortodontia e Ortopedia Facial, 2009, Vol 14, Issue 2, p39
- ISSN
1415-5419
- Publication type
Article
- DOI
10.1590/S1415-54192009000200005