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- Title
Gastrin-releasing peptide immunoreactivity in medullary thyroid carcinoma.
- Authors
Matsubayashi, Sunao; Yanaihara, Chizuko; Ohkubo, Masashi; Fukata, Shuji; Hayashi, Yoshio; Tamai, Hajime; Nakagawa, Tetsuya; Miyauchi, Akira; Kuma, Kanji; Abe, Kaoru; Suzuki, Toshimitsu; Yanaihara, Noboru; Matsubayashi, S; Yanaihara, C; Ohkubo, M; Fukata, S; Hayashi, Y; Tamai, H; Nakagawa, T; Miyauchi, A
- Abstract
Two cases of gastrin releasing peptide (GRP)-producing medullary thyroid carcinoma are presented. Immunohistochemical examination revealed the presence of GRP-like immunoreactivity (IR-GRP) in the primary tumor tissues. High concentration of IR-GRP was also demonstrated in extracts of the primary tumors by radioimmunologic means with use of a GRP-specific antiserum. Chromatographic analysis showed that the immunoreactivity was composed of at least two molecular forms: one behaved as synthetic porcine GRP on Sephadex G-50 gel filtration and the other as porcine GRP (14-27), a C-terminal active fragment of GRP. The IR-GRP was shown not to be attributed to bombesin-like immunoreactivity. Substance P-like immunoreactivity was not detected in the tumor tissues by either immunohistochemical or radioimmunologic means. This is, as far as the authors are aware, the first finding of IR-GRP as an ectopic product in medullary carcinoma.
- Publication
Cancer (0008543X), 1984, Vol 53, Issue 11, p2472
- ISSN
0008-543X
- Publication type
journal article
- DOI
10.1002/1097-0142(19840601)53:11<2472::AID-CNCR2820531118>3.0.CO;2-A