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- Title
Shrimp oil extracted from the shrimp processing waste reduces the development of insulin resistance and metabolic phenotypes in diet-induced obese rats.
- Authors
Nair, Sandhya; Gagnon, Jacques; Pelletier, Claude; Tchoukanova, Nadia; Zhang, Junzeng; Ewart, H. Stephen; Ewart, K. Vanya; Jiao, Guangling; Wang, Yanwen
- Abstract
Diet-induced obesity, insulin resistance, impaired glucose tolerance, chronic inflammation, and oxidative stress represent the main features of type 2 diabetes mellitus. The present study was conducted to examine the efficacy and mechanisms of shrimp oil on glucose homeostasis in obese rats. Male CD rats fed a high-fat diet (52 kcal% fat) and 20% fructose drinking water were divided into 4 groups and treated with the dietary replacement of 0%, 10%, 15%, or 20% of lard with shrimp oil for 10 weeks. Age-matched rats fed a low-fat diet (10 kcal% fat) were used as the normal control. Rats on the high-fat diet showed impaired ( p < 0.05) glucose tolerance and insulin resistance compared with rats fed the low-fat diet. Shrimp oil improved ( p < 0.05) oral glucose tolerance, insulin response, and homeostatic model assessment-estimated insulin resistance index; decreased serum insulin, leptin, hemoglobin A1c, and free fatty acids; and increased adiponectin. Shrimp oil also increased ( p < 0.05) antioxidant capacity and reduced oxidative stress and chronic inflammation. The results demonstrated that shrimp oil dose-dependently improved glycemic control in obese rats through multiple mechanisms.
- Subjects
INFLAMMATION prevention; ANIMAL experimentation; ANTIOXIDANTS; BLOOD sugar; DOSE-effect relationship in pharmacology; FATTY acids; FISH oils; FAT content of food; GLYCOSYLATED hemoglobin; HOMEOSTASIS; INSULIN; INSULIN resistance; OBESITY; PROBABILITY theory; RATS; SHELLFISH; LEPTIN; OXIDATIVE stress; GLUCOSE intolerance; ADIPONECTIN; DESCRIPTIVE statistics; GLYCEMIC control; IN vivo studies
- Publication
Applied Physiology, Nutrition & Metabolism, 2017, Vol 42, Issue 8, p841
- ISSN
1715-5312
- Publication type
Article
- DOI
10.1139/apnm-2016-0644