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- Title
A 12-month follow-up study on the preventive effect of oral lansoprazole on acute exacerbation of chronic obstructive pulmonary disease.
- Authors
Xiong, Wei; Zhang, Quan‐san; Zhao, Wei; Ding, Wei; Liu, Jin‐ming; Zhao, Yun‐feng
- Abstract
The objective of this study was to evaluate the preventive effects of oral administration of lansoprazole on acute exacerbation of chronic obstructive pulmonary disease ( COPD). Patients with COPD in groups C and D in the stable phase were stratified into a group with neither gastroesophageal reflux nor lansoprazole therapy (group A) and a group subjected to oral lansoprazole therapy (group B1) and a group not subjected to oral lansoprazole therapy (group B2). The frequency scale for the symptoms of gastroesophageal reflux disease ( FSSG) questionnaire, COPD assessment test (CAT) questionnaire, pulmonary function test and the 6-minute walk test were applied; in addition, arterial blood gas, white blood cell ( WBC), hs- CRP, liver function and the levels of IL-1β, IL-6, IL-8, TNF-α and GM- CSF in sputum were monitored during follow-up. In the 12-month follow-up period, the frequency of exacerbation in group B2 was statistically higher than that in groups A and B1 ( P < 0.05). After a 3-month follow-up, the score of groups A and B1 in the FSSG questionnaire was significantly lower than that of group B2 ( P < 0.05). After the 1-year follow-up, the CAT score, FEV1, 6-min walk test, the total number of WBC, hs- CRP, alanine aminotransferase, aspartate aminotransferase, pH of the arterial blood, PaO2, Pa CO2 and the levels of IL-1β, IL-6, IL-8, TNF-α and GM- CSF in the sputum were statistically different in group B2 compared with groups A and B1 ( P < 0.05). Oral lansoprazole therapy decreased the frequency of acute exacerbation of COPD by alleviating gastroesophageal reflux and lowering the levels of IL-1β, IL-6, IL-8, TNF-α and GM- CSF in the sputum.
- Subjects
OBSTRUCTIVE lung disease treatment; LANSOPRAZOLE; ALANINE aminotransferase; GASTROESOPHAGEAL reflux treatment; DISEASE exacerbation; PULMONARY function tests; THERAPEUTICS
- Publication
International Journal of Experimental Pathology, 2016, Vol 97, Issue 2, p107
- ISSN
0959-9673
- Publication type
Article
- DOI
10.1111/iep.12173