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- Title
Expression of OKM5 Antigen on Epidermal Cells in Mycosis Fungoides Plaque Stage.
- Authors
Lisby, Steen; Baadsgaard, Ole; Cooper, Kevin D.; Thomsen, Kristian; Wantzin, Gunhild R. Lange
- Abstract
To characterize and quantitate potential antigen-presenting cell subsets in the epidermis of patients with cutaneous T-cell lymphoma, epidermal cells in suspension were obtained from involved and uninvolved skin. Involved epidermis contained increased numbers of OKT6+HLA-D+ Langerhans cells and a variable number of OKM5+ epidermal cells (ECs) in all mycosis fungoides (MF) patients tested (N=14). The OKM5+ EC population from involved epidermis of MF patients were heterogeneous and comprised both OKM5+HLe1- keratinocytes and OKM5+HLe1+ leukocytes. Uninvolved epidermis, in 6 of 14 patients with MF, contained a small number of OKM5+ leukocytes; however no OKM5+ keratinocytes were detected. Neither OKM5+ leukocytes nor OKM5+ keratinocytes were detected in epidermis obtained from healthy controls. he increased number of potential antigen-presenting cells, that is, OKT6+HLA-DR+ Langerhans cells and OKM5+HLA-DR+ monocytic leukocytes, in the epidermis of patients with MF may be important for the activation of abnormal T cells contained within the epidermis of these patients. Such activated T cells may release &gamma:-interferon and induce expression of both HLA-DR and OKM5 antigens on keratinocytes. OKM5+ keratinocytes are present in the epidermis of patients with MF, but not in normal skin, and may thus play a role in the pathogenetic mechanisms of mycosis fungoides by recruitment of immunocompetent cells to the epidermis. J Invest Dermatol 90:716-719, 1988.
- Subjects
MYCOSIS fungoides; ANTIGENS; LYMPHOPROLIFERATIVE disorders; LANGERHANS cells; EPIDERMIS
- Publication
Journal of Investigative Dermatology, 1988, Vol 90, Issue 5, p716
- ISSN
0022-202X
- Publication type
Article
- DOI
10.1111/1523-1747.ep13083836