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- Title
Inflammatory cytokines in acute renal failure.
- Authors
Ramesh, Ganesan; Reeves, W. Brian
- Abstract
Inflammatory cytokines in acute renal failure. A growing body of evidence indicates that inflammatory mechanisms contribute to toxin-induced acute renal failure as well as ischemia/reperfusion injury. A role for tumor necrosis factor-α (TNF-α) in mediating the inflammatory injury in cisplatin-induced acute renal failure has recently been established. Cisplatin induces the expression of TNF-α and TNF receptor subtype 2 (TNFR2) within the kidney. Genetic deletion of either TNF-α or TNFR2 substantially reduces cisplatin-induced renal failure and also necrosis and apoptosis within the kidney. Studies will be required to determine if pharmacologic inhibition of TNF-α might reduce cisplatin-induced renal failure in humans.
- Subjects
CYTOKINES; CELLULAR immunity; IMMUNOREGULATION; ACUTE kidney failure; KIDNEY diseases; DISEASES
- Publication
Kidney International Supplement, 2004, Issue 91, pS56
- ISSN
0098-6577
- Publication type
Article
- DOI
10.1111/j.1523-1755.2004.09109.x