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- Title
Effect of generalized spike-and-wave discharge on glucose metabolism measured by positron emission tomography.
- Authors
Ochs, Rachel F.; Gloor, Pierre; Tyler, Jane L.; Wolfson, Tina; Worsley, Keith; Andermann, Frederick; Diksic, Mirko; Meyer, Ernst; Evans, Allan; Ochs, R F; Gloor, P; Tyler, J L; Wolfson, T; Worsley, K; Andermann, F; Diksic, M; Meyer, E; Evans, A
- Abstract
Positron emission tomography was used to study the cerebral metabolic rate for glucose (CMRGlc) in 7 adult patients with generalized spike-and-wave activity in the electroencephalogram. No consistent changes were seen in the CMRGlc. There was a slight trend toward an increased CMRGlc in 2 patients with primary generalized epilepsy, while in the 5 other patients with minor deviations from this condition or with secondary generalized epilepsy, the CMRGlc was unaffected by spike-and-wave activity or was below the normal range. Neither the amount of spike-and-wave activity in the EEG nor the presence of clinically evident absence seizures appeared to influence the CMRGlc. Therefore, we conclude that neuronal activity underlying spike-and-wave discharge does not seem to require increased glucose utilization.
- Subjects
ANTICONVULSANTS; BLOOD sugar; DEOXY sugars; ENERGY metabolism; EPILEPSY; EVOKED potentials (Electrophysiology); NEURONS; RADIOPHARMACEUTICALS; POSITRON emission tomography
- Publication
Annals of Neurology, 1987, Vol 21, Issue 5, p458
- ISSN
0364-5134
- Publication type
journal article
- DOI
10.1002/ana.410210508