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- Title
Sensory denervation reduces visceral hypersensitivity in adult rats exposed to chronic unpredictable stress: evidences of neurogenic inflammation.
- Authors
Ji-Hong Chen; Shao-Zhong Wei; Jian Chen; Qing Wang; Hui-Lan Liu; Xiao-Hai Gao; Guang-Can Li; Wen-Zhen Yu; Min Chen; He-Sheng Luo; Chen, Ji-Hong; Wei, Shao-Zhong; Chen, Jian; Wang, Qing; Liu, Hui-Lan; Gao, Xiao-Hai; Li, Guang-Can; Yu, Wen-Zhen; Chen, Min; Luo, He-Sheng
- Abstract
The purpose of this study is to provide evidence of neurogenic inflammation in chronic unpredictable stressed rats with the changes of visceral sensitivity, number of mast cells, and close proximity among mast cell-nerve-blood vessels. We found that (1) capsaicin denervation blocked stress-induced increase of visceral sensitivity, while doxantrazole presented a partial blocking; (2) capsaicin denervation blocked stress-induced enhancement of the proximity of mast cell-nerve fiber-blood vessels and blood vessel damage, while doxantrazole showed no effects on these; (3) doxantrazole blocked stress-induced increases of the MPO activity, the number and the degranulation of mast cells in the colon; (4) sensory denervation and doxantrazole had no effects on stress-induced behavioral inhibition. These results suggest that capsaicin-sensitive sensory fibers play a key role in stress-induced visceral hypersensitivity and the ultrastructural changes, mast cells play an important role in the generation of stress-induced colon inflammation.
- Subjects
NEUROGENIC bladder; BLADDER diseases; NEUROLOGIC manifestations of general diseases; PHYSIOLOGICAL stress -- Risk factors; INFLAMMATION; NEUROGENETICS; LABORATORY rats; BLOOD-vessel innervation; MAST cell physiology; ANIMAL experimentation; BEHAVIOR; CAPSAICIN; CELL physiology; COLON (Anatomy); DENERVATION; DRUGS; HETEROCYCLIC compounds; OXIDOREDUCTASES; RATS; SENSE organs; PHYSIOLOGICAL stress; PSYCHOLOGICAL stress; PHOSPHODIESTERASE inhibitors
- Publication
Digestive Diseases & Sciences, 2009, Vol 54, Issue 9, p1884
- ISSN
0163-2116
- Publication type
journal article
- DOI
10.1007/s10620-008-0575-5