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- Title
Antimicrobial Peptide, LL-37, And Its Potential As An Anti-HIV Agent.
- Authors
Vera-Cruz, Ana; Tanphaichitr, Nongnuj; Angel, Jonathan B.
- Abstract
Human immunodeficiency virus (HIV) continues to have a profound global health impact. New infections continue at a high rate despite the development of prophylactic therapies, prompting the need for development of novel preventative approaches. Antimicrobial peptides (AMPs), such as LL-37, display broad microbicidal properties and have potential as anti-HIV agents. LL-37 has been studied for its anti-HIV activity and the limited data available suggest it can inhibit HIV infection in primary T cells as well as exert inhibitory effects on key HIV enzymes. Its immunomodulatory properties may both enhance and inhibit HIV replication. In addition, LL-37 has both 1) the ability to kill other sexually-transmitted pathogens and 2) spermicidal activity; thus, it is a good candidate for multipurpose prevention technology. Further investigation of its anti-HIV activity is warranted.
- Subjects
ANTI-HIV agents; HIV infections; HIV; ANTIMICROBIAL peptides; T cells; PEPTIDE antibiotics; PROTEINS; ANTIBIOTICS
- Publication
Clinical & Investigative Medicine, 2021, Vol 44, Issue 3, pE64
- ISSN
0147-958X
- Publication type
journal article
- DOI
10.25011/cim.v44i3.36657