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- Title
Frequent truncating mutations of STAG2 in bladder cancer.
- Authors
Solomon, David A; Kim, Jung-Sik; Bondaruk, Jolanta; Shariat, Shahrokh F; Wang, Zeng-Feng; Elkahloun, Abdel G; Ozawa, Tomoko; Gerard, Julia; Zhuang, DaZhong; Zhang, Shizhen; Navai, Neema; Siefker-Radtke, Arlene; Phillips, Joanna J; Robinson, Brian D; Rubin, Mark A; Volkmer, Björn; Hautmann, Richard; Küfer, Rainer; Hogendoorn, Pancras C W; Netto, George
- Abstract
Here we report the discovery of truncating mutations of the gene encoding the cohesin subunit STAG2, which regulates sister chromatid cohesion and segregation, in 36% of papillary non-invasive urothelial carcinomas and 16% of invasive urothelial carcinomas of the bladder. Our studies suggest that STAG2 has a role in controlling chromosome number but not the proliferation of bladder cancer cells. These findings identify STAG2 as one of the most commonly mutated genes in bladder cancer.
- Subjects
BLADDER cancer genetics; GENE frequency; GENETIC mutation; GENETIC code; COHESINS; CANCER cell proliferation
- Publication
Nature Genetics, 2013, Vol 45, Issue 12, p1428
- ISSN
1061-4036
- Publication type
Article
- DOI
10.1038/ng.2800