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- Title
Genome-wide association analysis identifies three psoriasis susceptibility loci.
- Authors
Stuart, Philip E.; Nair, Rajan P.; Ellinghaus, Eva; Ding, Jun; Tejasvi, Trilokraj; Gudjonsson, Johann E.; Yun Li; Weidinger, Stephan; Eberlein, Bernadette; Gieger, Christian; Wichmann, H. Erich; Kunz, Manfred; Ike, Robert; Krueger, Gerald G.; Bowcock, Anne M.; Mrowietz, Ulrich; Lim, Henry W.; Voorhees, John J.; Abecasis, Gonçalo R.; Weichenthal, Michael
- Abstract
We carried out a meta-analysis of two recent psoriasis genome-wide association studies with a combined discovery sample of 1,831 affected individuals (cases) and 2,546 controls. One hundred and two loci selected based on P value rankings were followed up in a three-stage replication study including 4,064 cases and 4,685 controls from Michigan, Toronto, Newfoundland and Germany. In the combined meta-analysis, we identified three new susceptibility loci, including one at NOS2 (rs4795067, combined P = 4 × 10−11), one at FBXL19 (rs10782001, combined P = 9 × 10−10) and one near PSMA6-NFKBIA (rs12586317, combined P = 2 × 10−8). All three loci were also associated with psoriatic arthritis (rs4795067, combined P = 1 × 10−5; rs10782001, combined P = 4 × 10−8; and rs12586317, combined P = 6 × 10−5) and purely cutaneous psoriasis (rs4795067, combined P = 1 × 10−8; rs10782001, combined P = 2 × 10−6; and rs12586317, combined P = 1 × 10−6). We also replicated a recently identified association signal near RNF114 (rs495337, combined P = 2 × 10−7).
- Subjects
UNITED States; PSORIASIS; META-analysis; GENOMES; GENETICS; DISEASE susceptibility
- Publication
Nature Genetics, 2010, Vol 42, Issue 11, p1000
- ISSN
1061-4036
- Publication type
Article
- DOI
10.1038/ng.693