We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Analysis of the matrix metalloproteinase family reveals that MMP8 is often mutated in melanoma.
- Authors
Palavalli, Lavanya H.; Prickett, Todd D.; Wunderlich, John R.; Xiaomu Wei; Burrell, Allison S.; Porter-Gill, Patricia; Davis, Sean; Chenwei Wang; Cronin, Julia C.; Agrawal, Neena S.; Lin, Jimmy C.; Westbroek, Wendy; Hoogstraten-Miller, Shelley; Molinolo, Alfredo A.; Fetsch, Patricia; Filie, Armando C.; O'Connell, Michael P.; Banister, Carolyn E.; Howard, Jason D.; Buckhaults, Phillip
- Abstract
A mutational analysis of the matrix metalloproteinase (MMP) gene family in human melanoma identified somatic mutations in 23% of melanomas. Five mutations in one of the most commonly mutated genes, MMP8, reduced MMP enzyme activity. Expression of wild-type but not mutant MMP8 in human melanoma cells inhibited growth on soft agar in vitro and tumor formation in vivo, suggesting that wild-type MMP-8 has the ability to inhibit melanoma progression.
- Subjects
METALLOPROTEINASES; MELANOMA; CANCER cells; MOLECULAR genetics; GENE expression; GENETIC mutation; GENETIC research
- Publication
Nature Genetics, 2009, Vol 41, Issue 5, p518
- ISSN
1061-4036
- Publication type
Article
- DOI
10.1038/ng.340