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- Title
Aberrant IgG2 Antibody Response to Neisseria Meningitidis Polysaccharide A After Vaccination in Frequently Infected Compared to Healthy IgA-Deficient Individuals.
- Authors
Friman, V.; Hahn-Zoric, M.; Björkander, J.; Oxeliuss, V.-A.; Hanson, L. Å.
- Abstract
In search for a possible explanation of the phenotypic heterogeneity in selective immunoglobulin (Ig)A deficiency, we studied the IgG2 antibody response to meningococcal polysaccharide A (PSA) in IgA-deficient (IgAd) individuals after vaccination with meningococcal A + C polysaccharide vaccine. Two groups of IgAd individuals, one frequently infected and one clinically apparently healthy, as well as healthy controls, were studied. In response to meningococcal A + C polysaccharide vaccine, a significant titre increase of specific IgG2 anti-PSA was found in 71% of the control individuals, in 50% of the healthy and in 42% of the infection-prone IgAd individuals. The specific IgG2 response against meningococcal PSA was significantly lower in the infection-prone IgAd individuals compared to the controls ( P < 0.05). Among the IgAd individuals who responded with a significant IgG2 antibody increase, the IgG2 antibody response was significantly lower in the infection-prone than in the healthy IgAd individuals ( P < 0.05). Thus, a limited capacity to mount a specific IgG2 response may suggest a more profound antibody maturation defect in infection-prone IgAd patients compared to healthy IgAd individuals.
- Subjects
IMMUNOGLOBULIN A; NEISSERIA meningitidis; PREVENTIVE medicine; PREVENTION of communicable diseases; VACCINATION; INFECTION
- Publication
Scandinavian Journal of Immunology, 2004, Vol 60, Issue 3, p292
- ISSN
0300-9475
- Publication type
Article
- DOI
10.1111/j.0300-9475.2004.01459.x