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- Title
Activated CD3<sup>-</sup>CD16<sup>+</sup> Natural Killer Cells Express a Subset of the Lymphokine Genes Induced in Activated &chl;β<sup>+</sup> and γδ<sup>+</sup> T cells.
- Authors
Biassoni, R.; Ferrini, S.; Prigione, I.; Pelak, V. S.; Sekaly, R. P.; Long, E. O.
- Abstract
In this study we analysed the potential of highly purified polyclonal TcR αβ+, TcRγδ+ and CD3- NK cells, to produce lymphokines in response lo mitogenic stimulation. RNA hybridizations were performed to detect with high sensitivity the induction of multiple lymphokine genes. Upon stimulation with lectin and phorbol ester TcR γδ+ lymphocytes expressed the same set of lymphokine genes as the TcR αβ+ lymphocytes, which included IL-2,-3,-4,-5, GM-CSF. TNFα and β, IFNγ. In contrast, a more limited set of lymphokine genes (GM-CSF, TNFα and β, IFNγ) was induced in activated CD3- NK cells, thus indicating that this subpopulation of cells may display different regulatory functions, with respect to CD3+ T lymphocytes.
- Subjects
LYMPHOCYTES; GENES; HEREDITY; LEUCOCYTES; KILLER cells; CYTOKINES
- Publication
Scandinavian Journal of Immunology, 1991, Vol 33, Issue 3, p247
- ISSN
0300-9475
- Publication type
Article
- DOI
10.1111/j.1365-3083.1991.tb01769.x