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- Title
Experimentally Induced Transplantation Tolerance.
- Authors
Waterfield, J. D.; Bick, P. H.; E.Möller; Möller, G.
- Abstract
Neonatal tolerance was induced in CBA mice to alloantigens expressed by lymphoid cells of the A/Sn strain. 15% of the grafted animals maintained viable skin grafts for greater than 120 days and thus were considered operationally tolerant. However, splenic lymphocytes from these animals were capable of in vitro activation of DNA synthesis in response to the tolerizing alloantigens. Likewise, the spleen contained precursors of cytotoxic effector cells capable, upon activation, of similarly recognizing the major histocompatibility complex alloantigens used for tolerance induction. In contrast, in vivo graft-versus-host (GVH) effector function was absent, suggesting a possible dissociation of cells involved in the in vitro cell-mediated lympholysis and the in vivo GVH. Determination of potential serum-blocking factors as a possible mechanism of graft survival in these tolerant animals proved negative.
- Subjects
ANTIGENS; LYMPHOID tissue; SKIN grafting; LYMPHOCYTES; DNA synthesis; SPLEEN; MAJOR histocompatibility complex; GRAFT versus host disease
- Publication
Scandinavian Journal of Immunology, 1981, Vol 13, Issue 3, p211
- ISSN
0300-9475
- Publication type
Article
- DOI
10.1111/j.1365-3083.1981.tb00127.x