We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Integrated functional analysis of endometrial transcriptome, microbiome, and immune cell profiling is needed to dissect mechanisms of uterine pathologies and implantation failure.
- Authors
Acharya, Ganesh
- Abstract
The article discusses the need for an integrated functional analysis of the endometrial transcriptome, microbiome, and immune cell profiling to understand uterine pathologies and implantation failure. The human endometrium undergoes regular cyclical changes in response to hormones, resulting in changes in gene expression, microbiota composition, and immune cell profile. However, scientific breakthroughs in gynecology and reproductive medicine have been limited. Two studies mentioned in the article explore the association between endometrial transcriptome profiles and implantation outcomes, as well as the composition of microbiota in individuals with adenomyosis. The findings suggest potential associations, but the molecular mechanisms are not yet understood. An integrated functional approach is necessary to investigate the mechanisms of uterine pathologies and implantation failure.
- Subjects
EMBRYO implantation; FUNCTIONAL analysis; UTERINE hemorrhage; PATHOLOGY; TRANSCRIPTOMES; FECAL microbiota transplantation; GENITALIA; HYSTEROSCOPY
- Publication
Acta Obstetricia et Gynecologica Scandinavica, 2024, Vol 103, Issue 7, p1236
- ISSN
0001-6349
- Publication type
Article
- DOI
10.1111/aogs.14882