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- Title
Autophagy Activity in Pulmonary Metastatic Tumor Tissues from Colorectal Cancer: A Pilot Study.
- Authors
Young Sam Kim; Ju Hye Shin; Mi Kyung Bae; Chang Young Lee; Dae Joon Kim; Kyung Young Chung; Jin Gu Lee
- Abstract
Purpose: Autophagy has been reported to be involved in treatment failure in tumor. We aimed to evaluate autophagy activity in tumor tissue and compare them between the recurrence and non-recurrence groups. Materials and Methods: We analyzed expressions of autophagy-related proteins in tumor tissues which were obtained from pulmonary metastases of colorectal cancer patients by Western blot. We also analyzed autophagosomes by transmission electron microscopy. Results: Tumor tissues from recurrence group showed increased levels of LC3B-II, decreased levels of p62/SQSTM1, and also a marked accumulation of autophagosomes compared with tissues from non-recurrence group. Conclusion: The present study suggests that autophagy may be associated with treatment failure of metastatic colorectal cancer.
- Subjects
COLON cancer treatment; AUTOPHAGY; TUMOR proteins; COLON cancer patients; PILOT projects; COMPARATIVE studies; TRANSMISSION electron microscopy
- Publication
Yonsei Medical Journal, 2014, Vol 55, Issue 6, p1484
- ISSN
0513-5796
- Publication type
Article
- DOI
10.3349/ymj.2014.55.6.1484