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- Title
The Impact of Ulmus macrocarpa Extracts on a Model of Sarcopenia-Induced C57BL/6 Mice.
- Authors
Lee, Chan Ho; Kwon, Yeeun; Park, Sunmin; Kim, TaeHee; Kim, Min Seok; Kim, Eun Ji; Jung, Jae In; Min, Sangil; Park, Kwang-Hyun; Jeong, Jae Hun; Choi, Sun Eun
- Abstract
Aging leads to tissue and cellular changes, often driven by oxidative stress and inflammation, which contribute to age-related diseases. Our research focuses on harnessing the potent anti-inflammatory and antioxidant properties of Korean Ulmus macrocarpa Hance, a traditional herbal remedy, to address muscle loss and atrophy. We evaluated the effects of Ulmus extract on various parameters in a muscle atrophy model, including weight, exercise performance, grip strength, body composition, muscle mass, and fiber characteristics. Additionally, we conducted Western blot and RT-PCR analyses to examine muscle protein regulation, apoptosis factors, inflammation, and antioxidants. In a dexamethasone-induced muscle atrophy model, Ulmus extract administration promoted genes related to muscle formation while reducing those associated with muscle atrophy. It also mitigated inflammation and boosted muscle antioxidants, indicating a potential improvement in muscle atrophy. These findings highlight the promise of Ulmus extract for developing pharmaceuticals and supplements to combat muscle loss and atrophy, paving the way for clinical applications.
- Subjects
LABORATORY mice; MUSCULAR atrophy; BODY composition; MYOSITIS; GRIP strength; MUSCLE mass; SARCOPENIA
- Publication
International Journal of Molecular Sciences, 2024, Vol 25, Issue 11, p6197
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms25116197