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- Title
A simple method for evaluation of the uptake of isoflurane and its comparison with the square root of time model.
- Authors
Bangaari, Ashish; Panda, Nidhi Bidyut; Puri, Goverdhan Dutt
- Abstract
Background: The square root of time (SqRT) model had been used to predict the uptake of volatile agents. Methods: We studied the rate of uptake of isoflurane in 10 patients using liquid isoflurane infusion through syringe pump into the closed circuit. The infusion rates were titrated to maintain a constant end tidal concentration of isoflurane of 1.5%. The predicted uptake values were also calculated from the square root principle and compared with the derived uptake. Results: The observed rate of uptake was higher than predicted from the Lowe and Ernst equation (P<0.001). There exists considerable inter-individual variability in uptake pharmacokinetics and it showed statistically significant correlation with ideal body weight, body weight (P<0.01), body surface area, and body weight3/4 from 30 min of start of isoflurane infusion (P<0.05). Conclusion: SqRT model is inaccurate in predicting isoflurane uptake and underestimates it during closed circuit anaesthesia.
- Subjects
ISOFLURANE; SQUARE root; CONTINUOUS time models; SYRINGES; PHARMACOKINETICS; COMPARATIVE studies
- Publication
Indian Journal of Anaesthesia, 2013, Vol 57, Issue 3, p230
- ISSN
0019-5049
- Publication type
Article
- DOI
10.4103/0019-5049.115587