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- Title
Seizures in children with Down syndrome: etiology, characteristics and outcome.
- Authors
Stafstrom, Cart E.; Patxot, Omar F.; Gilmore, Herbert E.; Wisniewski, Krystyna E.; Stafstrom, C E; Patxot, O F; Gilmore, H E; Wisniewski, K E
- Abstract
Of 737 patients with Down syndrome, newborn to 22 years of age, 47 had a history of at least one seizure. Of those, 24 children had seizures with an identifiable etiology, usually related to a common medical complication of Down syndrome: neonatal hypoxia-ischemia, hypoxia from congenital heart disease, or infection. These acute medical illnesses may precipitate seizures in brains already predisposed to hyperexcitability because of abnormal neuronal development. It is recommended that all Down syndrome children with seizures undergo investigations to determine the etiology of the seizure.
- Publication
Developmental Medicine & Child Neurology, 1991, Vol 33, Issue 3, p191
- ISSN
0012-1622
- Publication type
journal article
- DOI
10.1111/j.1469-8749.1991.tb05108.x