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- Title
Case report: anti-glomerular basement membrane antibody disease with normal renal function.
- Authors
Nagano, China; Goto, Yoshimitu; Kasahara, Katuaki; Kuroyanagi, Yoshiyuki
- Abstract
<bold>Background: </bold>Anti-glomerular basement membrane (GBM) antibody disease is a rare autoimmune disorder characterized by rapidly progressive glomerulonephritis caused by autoantibodies against the α3-chain of type IV collagen in the GBM.<bold>Case Presentation: </bold>An 8-year-old girl with hematuria and proteinuria due to anti-GBM nephritis was diagnosed with hematuria and proteinuria during a school urine screening program. Her blood pressure and serum creatinine levels were normal. Her hematuria and proteinuria persisted for several months. Since a spot urine protein to creatinine ratio was around 7 g/g Cre, a percutaneous renal biopsy was performed. Immunofluorescent staining demonstrated a linear pattern for immunoglobulin G along the entire GBM. Chest computed tomography was normal. Anti-GBM antibody assays were reported as slightly raised; thus, the diagnosis was anti-GBM disease with normal renal function. Treatment included plasma exchange, intravenous high-dose methylprednisolone, and cyclophosphamide as a mainstay medication. The treatment was rapidly effective with an immediate decrease in anti-GBM titers and proteinuria.<bold>Conclusions: </bold>Cases of anti-GBM disease with normal renal function in children are rare. Treatment in children has not been established; therefore, clinicians need to carefully select an effective treatment because the prognosis is poor.
- Subjects
GLOMERULONEPHRITIS; TREATMENT of glomerulonephritis; BLOOD pressure; RENAL biopsy; PLASMA exchange (Therapeutics); TREATMENT effectiveness; DIAGNOSIS; HEMORRHAGE diagnosis; HEMORRHAGE treatment; LUNG disease diagnosis; LUNG disease treatment; ANTI-inflammatory agents; DIFFERENTIAL diagnosis; HEMORRHAGE; IMMUNOSUPPRESSIVE agents; INTRAVENOUS injections; LUNG diseases; CYCLOPHOSPHAMIDE; METHYLPREDNISOLONE
- Publication
BMC Nephrology, 2015, Vol 15, p1
- ISSN
1471-2369
- Publication type
journal article
- DOI
10.1186/s12882-015-0179-1