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- Title
Genome-wide association study of prolactin levels in blood plasma and cerebrospinal fluid.
- Authors
Staley, Lyndsay A.; Ebbert, Mark T. W.; Parker, Sheradyn; Bailey, Matthew; Ridge, Perry G.; Goate, Alison M.; Kauwe, John S. K.
- Abstract
Background: Prolactin is a polypeptide hormone secreted by the anterior pituitary gland that plays an essential role in lactation, tissue growth, and suppressing apoptosis to increase cell survival. Prolactin serves as a key player in many life-critical processes, including immune system and reproduction. Prolactin is also found in multiple fluids throughout the body, including plasma and cerebrospinal fluid (CSF). Methods: In this study, we measured prolactin levels in both plasma and CSF, and performed a genome-wide association study. We then performed meta-analyses using METAL with a significance threshold of p < 5 × 10-8 and removed SNPs where the direction of the effect was different between the two datasets. Results: We identified 12 SNPs associated with increased prolactin levels in both biological fluids. Conclusions: Our efforts will help researchers understand how prolactin is regulated in both CSF and plasma, which could be beneficial in research for the immune system and reproduction.
- Subjects
PROLACTIN; BLOOD plasma; CEREBROSPINAL fluid; PEPTIDE hormones; ANTERIOR pituitary gland; LACTATION; APOPTOSIS inhibition
- Publication
BMC Genomics, 2016, Vol 17, p287
- ISSN
1471-2164
- Publication type
Article
- DOI
10.1186/s12864-016-2785-0