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- Title
Lymphadenopathy Due to Penicillium Marneffei Infection: Diagnosis by Fine Needle Aspiration Cytology.
- Authors
Chaiwun, Benjaporn; Khunamornpong, Surapan; Sirivanichai, Chusak; Rangdaeng, Samreung; Supparatpinyo, Khuanchai; Settakorn, Jongolnee; Ya-in, Charm; Thorner, Paul
- Abstract
Penicillium marneffei is an opportunistic fungal infection that usually causes disseminated mainly in immunocompromised individuals, cially those with HIV infection. Untreated usually fatal. Diagnosis is traditionally opsy and/or culture; successful diagnosis by fine needle aspiration (FNA) has only been reported once. We present eight cases of HIV-infected patients with lymphadenopathy caused by P. marneffei infection, in which the diagnosis was made by FNA. In all cases, intracellular and extracellular yeast forms were visualized, and the characteristic cross-septation of P. manieffei was highlighted by GMS staining. All diagnoses were confirmed by culture. Anti-fungal treatment for P. marneffei was initiated, resulting in marked clinical improvement. We conclude that a diagnosis of lymphadenopathy caused by P. marneffei can reliably be made by FNA. The diagnosis is more rapid than biopsy or culture, allowing rapid institution of therapy, particularly important in immunocompromised patients. In all our cases, not only were lymphoma and other causes of lymphadenopathy ruled out, but also the necessity for an open surgical biopsy was obviated. This can be especially beneficial to patients (e.g., three in our study) in which lymphadenopathy is confined to deep intra-abdominal nodes.
- Subjects
HIV; PENICILLIUM; DIAGNOSIS; NEEDLE biopsy; CYTOLOGY; MYCOSES
- Publication
Modern Pathology, 2002, Vol 15, Issue 9, p939
- ISSN
0893-3952
- Publication type
Article
- DOI
10.1097/01.MP.0000027203.44333.95