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- Title
Efectividad de la solución de Jessner más ácido tricloroacético al 35% vs 5-fluorouracilo al 5% en queratosis actínicas faciales múltiples.
- Authors
Alfaro Orozco, Leticia Paulina; Alcalá Pérez, Daniel; Franco, Gisela Navarrete; González González, Maribet; Peralta Pedrero, María Luisa
- Abstract
Background: Actinic keratosis is the most common precancerous lesion in sun-exposed areas. The principal risk factor is cumulative exposure to ultraviolet radiation. If left untreated in 6 -16% develop into squamous cell carcinoma, and should be considered the precursors of at least 13 -- 60% of invasive squamous cell carcinoma. There are many lesion-directed therapy options, including cryotherapy, photodynamic therapy, imiquimod and 5-fluorouracil (5-FU). Chemical peel is an option in treating large areas with multiple keratosis. Objective: To compare effectiveness of 5-FU against Jessner's solution and 35% trichloroacetic acid (TCA), in patients with multiple actinic keratosis. Patients and method: We conduced a controlled trial that included 16 patients with multiple facial keratosis on both sides of the face. Right side was treated with daily applications of 5-FU cream for 6 weeks, and left side with a single application of Jessner's solution and 35% trichloroacetic acid. Results: We observed a complete resolution of actinic keratosis in 43.75% of the side treated with 5-FU, and 18.75% on the side treated with Jessner's solution and 35% TCA.
- Subjects
ACTINIC keratosis; FLUOROURACIL; ACETIC acid; ULTRAVIOLET radiation; SQUAMOUS cell carcinoma; COLD therapy; PHOTOCHEMOTHERAPY; THERAPEUTICS
- Publication
Dermatología Revista Mexicana, 2012, Vol 56, Issue 1, p44
- ISSN
0185-4038
- Publication type
Article