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- Title
A Randomized Controlled Trial of a 10 Percent CPP-ACP Cream to Reduce Mutans Streptococci Colonization.
- Authors
Pukallus, Margaret L.; Plonka, Kathryn A.; Holcombe, Trevor F.; Barnett, Adrian G.; Walsh, Laurence J.; W. Kim Seow
- Abstract
Purpose: The purpose of this study was to investigate the effectiveness of a 10 percent casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) cream to reduce mutans streptococci (MS) colonization and prevent early childhood caries. Methods: The cohort was randomized at mean age of 11 days old to receive once-daily CPP-ACP cream (N=102) or no product (comparison group; N=89) from the time of first tooth eruption. All mothers were contacted by telephone at six, 12, and 18 months and advised to brush their children's teeth twice daily with low-dose fluoride toothpaste. At 24 months, all children were examined at a community clinic. Results: At 24 months old, one out of 65 (2 percent) children in the CPP-ACP group had caries vs. four out of 58 (seven percent) in the comparison group (difference not statistically significant). There were fewer MS-positive children in the CPP-ACP group (26 percent) vs. the comparison group (47 percent; P=.02). A dose-response effect of CPP-ACP usage on MS was observed, where MS was present in eight percent of regular CPP-ACP users, 28 percent of irregular users, and 47 percent of non-users (P<.02). Conclusions: CPP-ACP reduced the percentages of mutans streptococci-positive 24-month-old children, although it did not reduce caries prevalence.
- Subjects
RANDOMIZED controlled trials; STREPTOCOCCUS mutans; DENTAL caries in children; CASEINS; PHOSPHOPEPTIDES; CALCIUM phosphate; SAMPLE size (Statistics); CONTROL groups
- Publication
Pediatric Dentistry, 2013, Vol 35, Issue 7, p550
- ISSN
0164-1263
- Publication type
Article