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- Title
Immunothrombotic dysregulation in chagas disease and COVID-19: a comparative study of anticoagulation.
- Authors
Pérez-Campos Mayoral, Laura; Hernández-Huerta, María Teresa; Papy-García, Dulce; Barritault, Denis; Zenteno, Edgar; Sánchez Navarro, Luis Manuel; Pérez-Campos Mayoral, Eduardo; Matias Cervantes, Carlos Alberto; Martínez Cruz, Margarito; Mayoral Andrade, Gabriel; López Cervantes, Malaquías; Vázquez Martínez, Gabriela; López Sánchez, Claudia; Pina Canseco, Socorro; Martínez Cruz, Ruth; Pérez-Campos, Eduardo
- Abstract
Chagas and COVID-19 are diseases caused by Trypanosoma cruzi and SARS-CoV-2, respectively. These diseases present very different etiological agents despite showing similarities such as susceptibility/risk factors, pathogen-associated molecular patterns (PAMPs), recognition of glycosaminoglycans, inflammation, vascular leakage hypercoagulability, microthrombosis, and endotheliopathy; all of which suggest, in part, treatments with similar principles. Here, both diseases are compared, focusing mainly on the characteristics related to dysregulated immunothrombosis. Given the in-depth investigation of molecules and mechanisms related to microthrombosis in COVID-19, it is necessary to reconsider a prompt treatment of Chagas disease with oral anticoagulants.
- Subjects
COVID-19; CHAGAS' disease; SARS-CoV-2; ORAL diseases; THERAPEUTICS
- Publication
Molecular & Cellular Biochemistry, 2021, Vol 476, Issue 10, p3815
- ISSN
0300-8177
- Publication type
Article
- DOI
10.1007/s11010-021-04204-3