We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Pathological and therapeutic aspects of matrix metalloproteinases: implications in childhood leukemia.
- Authors
Hsiao, Yi-Hsuan; Su, Shih-Chi; Lin, Chiao-Wen; Chao, Yu-Hua; Yang, Wei-En; Yang, Shun-Fa
- Abstract
Matrix metalloproteinases (MMPs) play a major role in extracellular matrix remodeling and are involved in tumor cell invasion. Cancers such as childhood leukemia are characterized by their capacity to infiltrate different organs. MMP production by leukemic cells may indicate a leukemic subtype or subpopulation with a more invasive phenotype. Therefore, clarifying the action mechanisms of MMPs as prognostic predictors or MMP targeting as a therapeutic strategy is necessary. MMP-targeting drugs have been developed for the treatment of hematological malignancies. In this review, we highlight current advances in understanding the molecular mechanisms and pathological characteristics of various MMPs, as well as recent therapeutic advances targeting MMPs in childhood leukemia. Several studies have been conducted on the therapeutic efficacy of MMP inhibitors in cancer, such as collagen peptidomimetics, nonpeptidomimetic inhibitors of MMP active sites, bisphosphonates, and tetracycline derivatives. Here, we conclude that more clinical trials are necessary to estimate the role of selective MMP inhibitors in the treatment and prevention of childhood leukemia.
- Subjects
MATRIX metalloproteinases; LEUKEMIA; TREATMENT effectiveness; CHILDHOOD cancer; HEMATOLOGIC malignancies
- Publication
Cancer & Metastasis Reviews, 2019, Vol 38, Issue 4, p829
- ISSN
0167-7659
- Publication type
Article
- DOI
10.1007/s10555-019-09828-y