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- Title
A ZnIn<sub>2</sub>S<sub>4</sub>/Ag<sub>2</sub>CO<sub>3</sub> Z-scheme heterostructure-based photoelectrochemical biosensor for neuron-specific enolase.
- Authors
Li, Jun; Liu, Shanghua; Dong, Hui; Li, Yueyuan; Liu, Qing; Wang, Shujun; Wang, Ping; Li, Yang; Li, Yueyun; Wei, Qin
- Abstract
An efficient photo-to-electrical signal is pivotal to photoelectrochemical (PEC) biosensors. In our work, a novel PEC biosensor was fabricated for the detection of neuron-specific enolase (NSE) based on a ZnIn2S4/Ag2CO3 Z-scheme heterostructure. Due to the overlapping band potentials of the ZnIn2S4 and Ag2CO3, the formed Z-scheme heterostructure can promote the charge separation and photoelectric conversion efficiency. And the concomitant Ag nanoparticles in Ag2CO3 provided multiple functions to enhance the PEC response of the Z-scheme heterostructure. It acts not only as a bridge for the transfer of carriers between ZnIn2S4 and Ag2CO3, promoting the constructed Z-scheme heterostructure, but also as electron mediators to accelerate the transfer of photogenerated carriers and improve the capture of visible light of the Z-scheme heterostructure by surface plasmon resonance (SPR). Compared with single Ag2CO3 and ZnIn2S4, the photocurrent of the designed Z-scheme heterostructure increased more than 20 and 60 times respectively. The fabricated PEC biosensor based on a ZnIn2S4/Ag2CO3 Z-scheme heterostructure exhibits sensitive detection to NSE, and presents a linear range of 50 fg·mL−1 ~ 200 ng·mL−1 with a limit of detection of 4.86 fg·mL−1. The proposed PEC biosensor provides a potential approach for clinical diagnosis.
- Subjects
BIOSENSORS; ENOLASE; SURFACE plasmon resonance; VISIBLE spectra
- Publication
Analytical & Bioanalytical Chemistry, 2023, Vol 415, Issue 22, p5551
- ISSN
1618-2642
- Publication type
Article
- DOI
10.1007/s00216-023-04830-4