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- Title
Mixed mucinous adenocarcinoma/large cell neuroendocrine carcinoma of the uterine cervix: case report and molecular characterization of a rare entity.
- Authors
Fattorini, Caterina; Rocca, Bruno J.; Giusti, Andrea; Arganini, Marco; Perotti, Bruno; Cavazzana, Andrea; Ambrosio, Maria R.; Volante, Marco
- Abstract
Mixed neuroendocrine-non-neuroendocrine carcinomas of the cervix are rare and generally aggressive diseases. They often present at an advanced stage with hematogenous or lymphatic metastases. The prognosis is poor, mostly influenced by the neuroendocrine component. Unfortunately, the rarity of the disease caused a lack of information about its pathogenesis and molecular landscape. The latest guidelines recommend a multimodal approach that usually includes radical surgery, platinum/etoposide-based chemotherapy, or chemoradiation. Here, we are presenting a case of metastatic mixed adenocarcinoma-large cell neuroendocrine carcinoma of the cervix in a 49-year-old female patient. The molecular characterization of the lesion highlighted the ubiquitous presence of human papillomavirus-18 DNA both in the adenocarcinomatous and the neuroendocrine components, suggesting a role for the virus in the pathogenesis. Moreover, a different set of mutations was detected in the two parts, thus ruling out a possible clonal evolution of the neuroendocrine component from the adenocarcinoma one. More studies are needed to clarify the molecular landscape of these rare lesions and identify putative targets for therapy.
- Subjects
NEUROENDOCRINE tumors; MUCINOUS adenocarcinoma; CERVIX uteri; NEUROENDOCRINE cells; LYMPHATIC metastasis
- Publication
Virchows Archiv: European Journal of Pathology, 2024, Vol 484, Issue 1, p141
- ISSN
0945-6317
- Publication type
Article
- DOI
10.1007/s00428-023-03532-7