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- Title
Effect of tumor volume on the enhancement pattern of parathyroid adenoma on parathyroid four-dimensional CT.
- Authors
Lee, Eun; Yun, Tae; Kim, Ji-hoon; Lee, Kyu; Kim, Su-jin; Won, Jae-Kyung; Kang, Koung; Choi, Seung; Sohn, Chul-Ho
- Abstract
Introduction: The purpose of this study is to assess the effect of tumor volume on the enhancement pattern of parathyroid adenoma (PTA) on four-dimensional computed tomography (4D-CT). Methods: We analyzed the enhancement patterns of PTA on four-phase 4D-CT in 44 patients. Dependency of the changes of Hounsfield unit values (ΔHU) on the tumor volumes and clinical characteristics was evaluated using linear regression analyses. In addition, an unpaired t test was used to compare ΔHU of PTAs between PTA volume ≥1 cm and <1 cm, thyroid gland, and lymph node. Results: PTA volume based on CT was the strongest factor on the ΔHU and ΔHU and ΔHU ( R = 0.34, 0.25, and 0.32, respectively, P < 0.001 for both). PTA ≥1 cm had statistically significant greater enhancement between the unenhanced phase and the arterial phase than PTA <1 cm (mean values ± standard deviations (SDs) of ΔHU, 102.7 ± 33.7 and 57.5 ± 28.8, respectively, P < 0.001). PTA ≥1 cm showed an early washout pattern on the venous phase, whereas PTA <1 cm showed a progressive enhancement pattern on the venous phase (mean values ± SDs of ΔHU, −13.2 ± 31.6 and 14.4 ± 32.7, respectively; P = 0.009). Conclusion: The enhancement pattern of PTA on 4D-CT is variable with respect to PTA volume based on CT. Therefore, the enhancement pattern of PTA on 4D-CT requires careful interpretation concerning the tumor volume, especially in cases of PTA <1 cm.
- Publication
Neuroradiology, 2016, Vol 58, Issue 5, p495
- ISSN
0028-3940
- Publication type
Article
- DOI
10.1007/s00234-016-1656-3