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- Title
In focus in HCB.
- Authors
Taatjes, Douglas J.; Roth, Jürgen
- Abstract
In their present work, Strnadová et al. ([23]) investigated the effect of melanoma cell-derived exosomes on cultured normal human dermal fibroblasts (HDF) and on melanoma-associated fibroblasts (mCAF) alone and in combination with melanoma cells. 1 Normalized invasion index of melanoma cells grown as spheroids with either melanoma-associated fibroblasts (mCAF) or normal human dermal fibroblasts (HDF). In this second Editorial for 2022, we will highlight three Original Articles describing (1) the effect of melanoma-produced exosomes on melanoma-associated fibroblasts compared to normal dermal fibroblasts, (2) exploitation of expression of altered focal adhesion kinase protein and mRNA for analysis of papillary thyroid carcinoma progression, and (3) detemination of the bioavailability time of thymidine analogues in an in vivo mouse model; and a Short Communication describing multimodal chemical analysis and machine learning to assess the effects of environmental pollutants on a soil earthworm model. Mixed 3D spheroids composed of G361 melanoma cells and either fibroblast type were exposed to a mixture of collagen-1 and G361-derived exosomes, and the melanoma cell invasion was evaluated after 144 h.
- Subjects
EXOSOMES; FIBROBLASTS; FOCAL adhesion kinase; URIDINE; EXTRACELLULAR matrix proteins; DISEASE progression; POLLUTANTS; INVERTEBRATES; MELANOMA; THYROID gland tumors; BIOAVAILABILITY; DEOXYRIBONUCLEOSIDES; SERIAL publications; MACHINE learning; CANCER; MESSENGER RNA; TRANSFERASES
- Publication
Histochemistry & Cell Biology, 2022, Vol 157, Issue 2, p123
- ISSN
0948-6143
- Publication type
Editorial
- DOI
10.1007/s00418-022-02075-3