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- Title
Under-Expression of CD24 in Pre-Eclamptic Placental Tissues Determined by Quantitative Real-Time RT-PCR.
- Authors
Nagy, Bálint; Berkes, Enikő; Rigó, Barbara; Bán, Zoltán; Papp, Zoltán; Hupuczi, Petronella
- Abstract
Background: Pre-eclampsia is a pregnancy-related disorder present in about 5–7% of all pregnancies. CD24 expression was recently reported in different diseases, while it has not yet been determined in pre-eclamptic placental tissues. Methods: We collected placental tissues from pre-eclamptic (n = 16) and healthy pregnancies (n = 16). We used the quantitative real-time PCR method with a primer-probe system for determination of CD24 gene expression. Results: We measured CD24 concentrations of 18.94 ± 26.86 ng/μl in the pre-eclamptic and 53.85 ± 92.05 ng/μl in the healthy placental tissues (p = 0.03). Conclusions: The quantitative real-time PCR method is suitable to determine CD24 expression in placental tissues. We suppose the low expression of CD24 may cause the enhanced immune reaction and could play a role in the abnormal development of placenta in pre-eclampsia. Copyright © 2008 S. Karger AG, Basel
- Subjects
PREECLAMPSIA; PLACENTA; POLYMERASE chain reaction; TISSUES; PREGNANCY
- Publication
Fetal Diagnosis & Therapy, 2008, Vol 23, Issue 4, p263
- ISSN
1015-3837
- Publication type
Article
- DOI
10.1159/000123612